Tag Archives: animal research and ethics

Should We Boil Lobsters Alive?

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If the UK joins a handful of other nations to recognize the sentience of invertebrates, such as cephalopod mollusks and decapod crustaceans, by, for example, prohibiting the boiling of live lobsters, this will be based on evidence that emotions and felt experiences (i.e., sentience) are not limited to animals close to humans, such as the mammals.

Over a decade ago, the same debate revolved around fish. Do fish feel pain? …This debate was settled when fish were found to learn from encounters with negative stimuli by avoiding dangerous locations. The best explanation is that fish remember these locations because they felt and neuronally processed aversive experiences. The same logic has been followed for arthropods, such as crabs, which in experiments learn to avoid locations where they have been shocked…

For example, the face—the proverbial window on human emotions—expresses emotions through similar muscular contractions…indistinguishable between humans and chimpanzees. Obviously, increasingly distant species have increasingly different expressions of the emotions, but research has found that, for example, physiological changes, lowered temperature of the extremities, and activation of the amygdala during fear are notably similar in fearful rats and fearful humans…. 

Bees subjected to vigorous physical agitation (shaking) to simulate a predatory attack proved less willing to explore new tastes, and hence were negatively biased by their experience. They also showed reduced amounts of hemolymph dopamine, octopamine, and serotonin. Changes in these neurotransmitters mark anxiety or depression in humans.

 It is not hard to see that the denial of animal emotions, and by extension animal feelings, has been morally convenient during human’s history of animal exploitation. Conversely, their recognition is bound to shake up our moral decision-making…If crabs experience emotional states, then they have an interest in these states being positively valenced. Current research indicates that a wide range of animals have interests in avoiding felt pain, and that they would not consent to painful procedures if given the opportunity….

When the medical community recognized infant pain in the 1980s, it was because the evidence was so overwhelming that physicians could no longer act as if infants are immune to pain.

Excerpts from Frans BM de Waal and Kristin Andrews, The question of Animal Emotions, Science, Mar. 25, 2022

Relentless Efficiency: the View of Pigs

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Gestation crates for pigs are typically about two feet wide and prevent sows from turning around, maximizing use of available space. Some producers say it also prevents the pigs from harming one another. Breeding pigs can produce seven or more piglets per litter, totaling well over 60 piglets in consecutive pregnancies over a few years. Widespread use of gestation crates began in the 1970s as pork producers gave priority to efficiency. A 1978 article in the industry publication National Hog Farmer suggested producers consider the sow “a valuable piece of machinery whose function is to pump out baby pigs like a sausage machine.”

“Under that mind-set, the industry went, no pun intended, hog wild into moving pigs into gestation crates,” says Matthew Prescott, senior director of food and agriculture for the Humane Society, who has been focused on eliminating the crates since 2002.

Excerpt from Cara Lombardo, Relentless Wall Street Billionaire Has a Secret Cause, WSJ, Feb. 8, 2021

The Necessity of the Evil: Breeding Monkeys to Experiment with their Brains

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In 2014 a German animal-rights group called soko Tierschutz planted a caretaker in the laboratory of Nikos Logothetis, a neuroscientist working at the Max Planck Institute in Tübingen. The infiltrator secretly filmed around 100 hours of lab work over six months, some of which was later broadcast on German television. The footage showed monkeys with metal plugs grafted into their skulls—ports which researchers used to probe and study their brains. One vomits on camera, apparently as a result of damage done to blood vessels in its brain while electrodes were inserted.

The impact was immediate and lasting. Around 800 people massed outside Dr Logothetis’s lab, demanding an end to his work with monkeys. He was called a monster and a murderer. He and his family received death threats. He faced charges (which were dismissed) of breaking German animal-welfare laws. So in 2020 he announced that his laboratory would move to China. He is building a new research facility in Shanghai, working with Mu-ming Poo of the Institute of Neuroscience, one of China’s leading brain researchers, who was on the team responsible for first cloning a genetically modified primate in 2018. 

In East Asia, particularly China and Japan, the volume of research carried out on monkeys is growing. Most of this has been driven by creating and expanding domestic primate-research programmes. Leading institutions such as the Shanghai Institute of Neuroscience focus on breeding monkeys whose genomes have been modified in order to make their physiology more like humans’ and so more useful for studying human diseases.

The social nature of monkeys and their intelligence—which is why they are so useful for research—also help explain why such experiments are so troubling. Research which relies on them is simultaneously more valuable and more ethically fraught than research on other creatures. Neuroscientists in particular consider monkeys irreplaceable. The brain is so poorly understood that looking at its activity in living creatures is the only way to fathom how it works, says Dr Treue. Dissecting dead brains produces only limited information. Brains only really make sense when active. Few humans would volunteer to have electrodes implanted in their brains. The consent of any who did would be suspect….

The list of medical advances which rest on animal experimentation is long, but Dr Bennett points to one in particular that could not have happened without monkeys: prosthetic limbs which “talk” to the brain, known as neural prosthetics. The brains of non-human primates are sufficiently similar to ours to allow for a prosthetic developed on monkeys to be used by humans. They are still rare, but prototypes have restored the power to interact with the physical world to people who have lost the use of their own limbs.

China is becoming the global centre for the kind of neuroscience that uses monkeys. And the stakes are getting higher. Neurological disorders are the world’s second-leading cause of death after heart disease. Conditions such as Parkinson’s disease, Alzheimer’s and dementia are becoming more burdensome as the world gets greyer. Meanwhile technology companies hope that an understanding of the brain can help them build cleverer software. Generals think advances in neuroscience can help them build better weapons.

The pandemic has bolstered China’s position. In February 2020 China’s government banned the export of all wild animals in an effort to tamp down the wildlife trade that is thought to be a vector for the zoonotic spillover of pathogens such as sars-cov-2, the virus that causes covid-19. Exceptions for research are subject to the government’s approval. Until recently the majority of monkeys used in America were imported from farms in China. But export controls have created shortages. China has decided that research primates are a strategic resource. Exports are unlikely to revert to their previous levels…America and Europe may find themselves outsourcing the creation of knowledge that relies on research methods they consider unethical. In future they may have to choose between relying on the fruits of that knowledge, such as treatments for neurological disorders, and rejecting them in principle….

Excerpt from Money Business: Attitudes towards experimenting on monkeys are diverging, Economist, July 24, 2021