Tag Archives: bioengineered food

Genetically Modified Crops May Become the Norm: the case of Golden Rice

Golden Rice is a genetically modified (GM) crop that could help prevent childhood blindness and deaths in the developing world. Ever since Golden Rice first made headlines nearly 20 years ago, it has been a flashpoint in debates over GM crops. Advocates touted it as an example of their potential benefit to humanity, while opponents of transgenic crops criticized it as a risky and unnecessary approach to improve health in the developing world.

Now, Bangladesh appears about to become the first country to approve Golden Rice for planting..Golden Rice was developed in the late 1990s by German plant scientists Ingo Potrykus and Peter Beyer to combat vitamin A deficiency, the leading cause of childhood blindness. Low levels of vitamin A also contribute to deaths from infectious diseases such as measles. Spinach, sweet potato, and other vegetables supply ample amounts of the vitamin, but in some countries, particularly those where rice is a major part of the diet, vitamin A deficiency is still widespread; in Bangladesh it affects about 21% of children.

To create Golden Rice, Potrykus and Beyer collaborated with agrochemical giant Syngenta to equip the plant with beta-carotene genes from maize. They donated their transgenic plants to public-sector agricultural institutes, paving the way for other researchers to breed the Golden Rice genes into varieties that suit local tastes and growing conditions.

The Golden Rice under review in Bangladesh was created at the International Rice Research Institute (IRRI) in Los Baños, Philippines. Researchers bred the beta-carotene genes into a rice variety named dhan 29…Farmers in Bangladesh quickly adopted an eggplant variety engineered to kill certain insect pests after its 2014 introduction, but that crop offered an immediate benefit: Farmers need fewer insecticides. Golden Rice’s health benefits will emerge more slowly,

Excerpts from Erik Stokstad,  After 20 Years, Golden Rice Nears Approval, Science,  Nov. 22, 2019

Modernize or Die: Bio-Engineered Food

China is betting that CRISP technology*can transform the country’s food supply.  China also expanded its efforts beyond its borders in 2017, when the state-owned company ChemChina bought Switzerland-based Syngenta—one of the world’s four largest agribusinesses, which has a large R&D team working with CRISPR—for $43 billion. That was the most China has ever spent on acquiring a foreign company, and it created an intimate relationship between government, industry, and academia—a “sort of a ménage à trois” that ultimately could funnel intellectual property from university labs into the company, says plant geneticist Zachary Lippman of Cold Spring Harbor Laboratory in New York.

Chinese leaders “want to strategically invest in genome editing, and [by that] I mean, catch up,” says Zhang Bei, who heads a team of 50 scientists at the Syngenta Beijing Innovation Center…China may one day need CRISPR-modified plants to provide enough food for its massive population….    China needs to resolve how it will regulate CRISPR-engineered crops—a divisive issue in many countries. In a 2018 decision that rocked big agriculture, a European court ruled that such crops are genetically modified organisms (GMOs) that need strict regulation. In contrast, the U.S. Department of Agriculture (USDA) exempts genome-edited plants from regulations covering GMOs as long as they were produced not by transferring DNA from other species, but by inducing mutations that could have occurred naturally or through conventional breeding.  Chinese consumers are wary of GM food. The country strictly limits the import of GM crops, and the only GM food it grows are papayas for domestic consumption. But for CRISPR, many plant researchers around assume China will follow in the United States’s footsteps…

For Corteva, Syngenta, and the other two big ag companies—BASF and Bayer (which acquired Monsanto last year)—the long game is to use CRISPR to develop better versions of their serious moneymakers, the “elite” varieties of a wide range of crops that have big commercial markets. They sell dozens of kinds of elite corn seeds—for example, inbred strains that consistently have high yields or reliable resistance to herbicides. Creating the genetic purity needed for an elite variety typically takes traditional breeding of many generations of plants, and CRISPR is seen as the cleanest way to improve them quickly. The earlier methods of engineering a plant can lead to unwanted genomic changes that must be laboriously culled…

Syngenta sees CRISPR-modified corn as a big opportunity in China, which grows more hectares of corn than any other crop. Yields per hectare are only 60% of those in the United States because corn ear worms often weaken Chinese crops. A fungus thrives in the weakened plants, producing a toxin that makes the resultant ears unfit for animal feed. As a result, China must import a great deal of corn. (According to USDA, 82% of U.S.-grown corn has been engineered to have a bacterial gene that makes it resistant to ear worms.)…“Syngenta is putting a lot of emphasis to grow in China to become the leading seed company. The China market as a whole, if it modernizes as the U.S. has modernized, can be as big as the U.S. market.”

Jon Cohen, To feed its 1.4 billion, China bets big on genome editing of crops, Science Magazine, Aug. 2, 2019

* Genome editing (also called gene editing) is a group of technologies that give scientists the ability to change an organism’s DNA. These technologies allow genetic material to be added, removed, or altered at particular locations in the genome. Several approaches to genome editing have been developed. A recent one is known as CRISPR-Cas9.

Sequencing All Species: the Earth BioGenome Project

In the first attempt of its kind, researchers plan to sequence all known species of eukaryotic life—66,000 species of animals, plants, fungi, and protozoa—in a single country, the United Kingdom. The announcement was made here today at the official launch of an even grander $4.7 billion global effort, called the Earth BioGenome Project (EBP), to sequence the genomes of all of Earth’s known 1.5 million species of eukaryotes within a decade.

In terms of genomes sequenced, the eukaryotes—the branch of complex life consisting of organisms with cells that have a nucleus inside a membrane—lag far behind the bacteria and archaea. Researchers have sequenced just about 3500 eukaryotic genomes, and only 100 at high quality.

The U.K. sequencing effort—dubbed The Darwin Tree of Life project—will now become part of the EBP mix…Also announced today was a memorandum of understanding for participating in EBP. It has been signed by 19 institutions, including BGI Shenzhen, China; the Royal Botanic Gardens, Kew; and Sanger. 

Excerpts from Erik Stokstad, Researchers launch plan to sequence 66,000 species in the United Kingdom. But that’s just a start, Science, Nov. 1, 2018

Illegal Genetically Modified Crops: China

In 2013 President Xi Jinping of China…recounted his own experience of hunger during China’s great famine in the early 1960s…..He said that guaranteeing China’s “food security” was still a serious worry. Hinting at what he saw as a possible remedy, he said China must “occupy the commanding heights of transgenic technology” and not yield that ground to “big foreign firms”….

Since then, however, Chinese policy had grown much more conservative, for two main reasons. The first is anxiety among some members of the public about the safety of GM foods. The other is a worry that China’s food market might become reliant on foreign GM technology. True, a large share of the soyabeans imported by China are genetically modified. So is the vast majority of the cotton it grows. In 2015 there were more than 6.6m farmers growing GM cotton, and a total of 3.7m hectares of GM crops under cultivation, including cotton and papaya, according to Randy Hautea of the International Service for the Acquisition of Agri-biotech Applications, an industry group. But the government has been reluctant to approve the growing of GM staples such as maize (corn) and rice.   …

Worries about foreign domination of GM technology may ease if a $43 billion deal reached in February 2016 goes ahead for the takeover of Syngenta, a Swiss agricultural firm, by a Chinese company, ChemChina. The acquisition must still be approved by regulators in several countries, but it could give China control of Syngenta’s valuable GM-seed patents.

China’s policymakers may be trying to bring belated order to what is already thought to be the widespread, illegal, growing of GM crops. Greenpeace, an NGO, reported in January 2016 that 93% of samples taken from maize fields in Liaoning province in the north-east tested positive for genetic modification, as did nearly all the seed samples and maize-based foods it gathered at supermarkets in the area.

Excerpts from Genetically Modified Crops: Gene-Policy Transfer, Economist,  Apr. 23, 2016